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Proteins. 2005;61 Suppl 7:143-51.

Prediction of novel and analogous folds using fragment assembly and fold recognition.

Author information

1
Department of Computer Science, University College London, London, United Kingdom. dtj@cs.ucl.ac.uk

Abstract

A number of new and newly improved methods for predicting protein structure developed by the Jones-University College London group were used to make predictions for the CASP6 experiment. Structures were predicted with a combination of fold recognition methods (mGenTHREADER, nFOLD, and THREADER) and a substantially enhanced version of FRAGFOLD, our fragment assembly method. Attempts at automatic domain parsing were made using DomPred and DomSSEA, which are based on a secondary structure parsing algorithm and additionally for DomPred, a simple local sequence alignment scoring function. Disorder prediction was carried out using a new SVM-based version of DISOPRED. Attempts were also made at domain docking and "microdomain" folding in order to build complete chain models for some targets.

PMID:
16187356
DOI:
10.1002/prot.20731
[Indexed for MEDLINE]

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