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J Ind Microbiol Biotechnol. 2006 Feb;33(2):105-20. Epub 2005 Sep 27.

Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites.

Author information

1
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

Abstract

Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs. In this article we review the incorporation of glycerol-derived precursors into polyketides and propose new mechanisms for the incorporation processes.

PMID:
16187096
DOI:
10.1007/s10295-005-0026-7
[Indexed for MEDLINE]

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