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Neurology. 2005 Sep 27;65(6):925-7.

Painful small-fiber neuropathy in Sjogren syndrome.

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  • 1Department of Neurology, University of Rochester, Rochester, NY, USA.


Of 20 consecutive patients with Sjögren neuropathy, 16 (80%) presented with burning feet and 12 (60%) with non-length-dependent sensory symptoms. Leg and thigh skin biopsies, performed in 13 patients, including 7 with normal electrophysiology, showed either reduced epidermal nerve fiber (ENF) density or abnormal morphology. ENF loss was frequently non length dependent, suggesting that patients with this disorder commonly have a small-fiber sensory neuronopathy rather than a "dying-back" axonopathy.

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