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Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14458-62. Epub 2005 Sep 26.

Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops.

Author information

1
Max Planck Institute for Molecular Plant Physiology, D-14424 Golm, Germany.

Abstract

There is current debate whether genetically modified (GM) plants might contain unexpected, potentially undesirable changes in overall metabolite composition. However, appropriate analytical technology and acceptable metrics of compositional similarity require development. We describe a comprehensive comparison of total metabolites in field-grown GM and conventional potato tubers using a hierarchical approach initiating with rapid metabolome "fingerprinting" to guide more detailed profiling of metabolites where significant differences are suspected. Central to this strategy are data analysis procedures able to generate validated, reproducible metrics of comparison from complex metabolome data. We show that, apart from targeted changes, these GM potatoes in this study appear substantially equivalent to traditional cultivars.

PMID:
16186495
PMCID:
PMC1242293
DOI:
10.1073/pnas.0503955102
[Indexed for MEDLINE]
Free PMC Article

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