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J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):65-75. Epub 2005 Sep 23.

Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.

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Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce-Padiglione E, Via Brunamonti 51, 06122 Perugia Italy.


According to the free radical theory, aging can be considered as a progressive, inevitable process partially related to the accumulation of oxidative damage into biomolecules -- nucleic acids, lipids, proteins or carbohydrates -- due to an imbalance between prooxidants and antioxidants in favor of the former. More recently also the pathogenesis of several diseases has been linked to a condition of oxidative stress. In this review we focus our attention on the evidence of oxidative stress in aging brain, some of the most important neurodegenerative diseases -- Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) -- and in two common and highly disabling vascular pathologies--stroke and cardiac failure. Particular attention will be given to the current knowledge about the biomarkers of oxidative stress that can be possibly used to monitor their severity and outcome.

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