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Bioorg Med Chem Lett. 2005 Dec 1;15(23):5237-40. Epub 2005 Sep 23.

Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor.

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1
Department of Medicinal Chemistry, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, USA.

Abstract

Synthesis and structure-activity relationship studies of a series of cyclohexylpiperazines bearing an amide side chain as ligands of the MC4 receptor are discussed. Compounds such as 11i from this series are potent agonists (EC(50)=33nM, IA=96%).

PMID:
16183282
DOI:
10.1016/j.bmcl.2005.08.061
[Indexed for MEDLINE]
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