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J Pediatr. 2005 Sep;147(3):316-20.

Gestational and neonatal characteristics of children with cystic fibrosis: a cohort study.

Author information

1
Cystic Fibrosis Center of Tuscany, Pediatric Infectious Diseases Department, Meyer Pediatric Hospital, University of Florence, Italy. f.festini@meyer.it

Abstract

OBJECTIVE:

To examine whether the birth weight (BW) and the risks of being pre-term, low birth weight (LBW), and small for gestational age (SGA) of children with cystic fibrosis (CF) are different from nonaffected children.

STUDY DESIGN:

Retrospective cohort study. We examined all the children with CF born in Tuscany, Italy, from 1991 to 2002 (n = 70) comparing them to the entire population of non-CF-affected children born in the same period (n = 290,059).

RESULTS:

The mean BW of newborns with CF was 246.2 g lower than the mean BW of the non-CF neonatal population (P = .0003). Children with CF had a higher risk of being born pre-term (RR 2.62, P = .001), LBW (RR 2.66, P = .0009), and SGA (RR = 1.74, P = .04) than the non-CF-affected children. The mean BW of term newborns with CF was 205.7 g lower than that of term non-CF-affected babies (P = .0002).

CONCLUSIONS:

Our data show an association between CF and reduced BW and show a greater risk of being pre-term for babies with CF.

PMID:
16182668
DOI:
10.1016/j.jpeds.2005.04.031
[Indexed for MEDLINE]

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