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J Cell Sci. 2005 Oct 1;118(Pt 19):4327-32.

mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria.

Author information

1
Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. hanita@cc.huji.ac.il

Abstract

mazEF is a toxin-antitoxin module located on the Escherichia coli chromosome and that of some other bacteria, including pathogens. mazF specifies for a stable toxin, MazF, and mazE specifies for a labile antitoxin, MazE, that antagonizes MazF. MazF is a sequence-specific mRNA endoribonuclease that initiates a programmed cell death pathway in response to various stresses. The mazEF-mediated death pathway can act as a defense mechanism that prevents the spread of bacterial phage infection, allowing bacterial populations to behave like multicellular organisms.

PMID:
16179604
DOI:
10.1242/jcs.02619
[Indexed for MEDLINE]
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