Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2005 Oct 28;310(5748):667-70. Epub 2005 Sep 22.

Antagonistic actions of ecdysone and insulins determine final size in Drosophila.

Author information

1
CNRS/University of Nice-Sophia Antipolis, UMR6543, Parc Valrose, 06108 Nice Cedex 2, France.

Abstract

All animals coordinate growth and maturation to reach their final size and shape. In insects, insulin family molecules control growth and metabolism, whereas pulses of the steroid 20-hydroxyecdysone (20E) initiate major developmental transitions. We show that 20E signaling also negatively controls animal growth rates by impeding general insulin signaling involving localization of the transcription factor dFOXO and transcription of the translation inhibitor 4E-BP. We also demonstrate that the larval fat body, equivalent to the vertebrate liver, is a key relay element for ecdysone-dependent growth inhibition. Hence, ecdysone counteracts the growth-promoting action of insulins, thus forming a humoral regulatory loop that determines organismal size.

PMID:
16179433
DOI:
10.1126/science.1119432
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center