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Clin Exp Immunol. 2005 Oct;142(1):12-20.

The paradox of matrix metalloproteinases in infectious disease.

Author information

1
Department of Infectious Diseases, Hammersmith Campus, Imperial College, London, UK.

Abstract

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that perform multiple roles in the normal immune response to infection. MMPs facilitate leucocyte recruitment, cytokine and chemokine processing, defensin activation and matrix remodelling. However, excess MMP activity following infection may lead to immunopathology that causes host morbidity or mortality and favours pathogen dissemination or persistence. Here, we review the normal functions of MMPs in immunity and then discuss viral and bacterial infections where excess MMP activity has been implicated in pathology, specifically examining HIV, HTLV-1, hepatitis B, endotoxin shock, Helicobacter pylori and Mycobacterium tuberculosis. Tissue destruction may be exacerbated further by bacterial-derived enzymes which activate the host pro-MMPs. Finally, the potential for therapeutic targeting of excess MMP activity in infection is considered.

PMID:
16178851
PMCID:
PMC1809491
DOI:
10.1111/j.1365-2249.2005.02840.x
[Indexed for MEDLINE]
Free PMC Article

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