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Org Lett. 2005 Sep 29;7(20):4487-9.

One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling.

Author information

1
Chemical Resources Laboratory, Tokyo Institute of Technology, R1-4 4259 Nagatsuta, Yokohama 226-8503, Japan.

Abstract

[reaction: see text] Four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide, and an aryl iodide furnishes pyrazole or isoxazole derivatives in the presence of a palladium catalyst. The reaction proceeds at room temperature and an ambient pressure of carbon monoxide in an aqueous solvent system.

PMID:
16178565
DOI:
10.1021/ol051841j
[Indexed for MEDLINE]
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