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Clin Chim Acta. 2006 Mar;365(1-2):346-9. Epub 2005 Sep 19.

The formation and rapid clearance of a truncated albumin species in a critically ill patient.

Author information

1
Swedish Medical Center, Trauma Research Laboratory, 501 E. Hampden Ave., Englewood, CO 80113, USA. dbaror@dmibio.com

Abstract

INTRODUCTION:

Hypoalbuminemia is known to occur in critically ill patients and is associated with increased mortality. We observed a potentially novel, partial explanation for the hypoalbuminemia noticed in a severely traumatized patient.

CASE REPORT:

We report of a severely, multi-system traumatized patient in whom hypoalbuminemia was present (1-2 g/dl). The plasma albumin (HSA) was analyzed by liquid chromatography/positive electrospray ionization mass spectrometry. A high percentage of a truncated albumin that lost its carboxy terminal amino acid leucine (HSA-L) associated with a 10-fold increase in plasma carboxypeptidase A (CPA) activity (R(2)=0.994) were found. We estimated the half life of this truncated albumin species to be <80 h.

CONCLUSIONS:

The increased CPA activity encountered following a traumatic event and subsequent rapid clearance of the resulting HSA-L from plasma might be a contributing factor to the hypoalbuminemia observed in the critically ill patients.

PMID:
16176812
DOI:
10.1016/j.cca.2005.08.011
[Indexed for MEDLINE]

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