Format

Send to

Choose Destination
See comment in PubMed Commons below
Physiology (Bethesda). 2005 Oct;20:349-56.

The bone marrow vascular niche: home of HSC differentiation and mobilization.

Author information

1
Weill Medical College of Cornell University, New York, New York, USA.

Abstract

The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.

PMID:
16174874
DOI:
10.1152/physiol.00025.2005
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center