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BMC Genet. 2005 Sep 20;6:46.

MAOA haplotypes associated with thrombocyte-MAO activity.

Author information

1
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. marten.jansson@cmm.ki.se

Abstract

BACKGROUND:

The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).

RESULTS:

Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.

CONCLUSION:

The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-chromosome inactivation at this locus. It is plausible that a gene-dosage effect can provide some insight into the greater prevalence of depressed state in females than males.

PMID:
16174289
PMCID:
PMC1249565
DOI:
10.1186/1471-2156-6-46
[Indexed for MEDLINE]
Free PMC Article

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