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J Am Chem Soc. 2005 Sep 28;127(38):13164-6.

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.

Author information

1
Department of Chemistry, Northwestern University, Evanston, Illinois 60201, USA.

Abstract

We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.

PMID:
16173742
DOI:
10.1021/ja051294x
[Indexed for MEDLINE]

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