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J Am Chem Soc. 2005 Sep 28;127(38):13148-9.

A route to annulated indoles via a palladium-catalyzed tandem alkylation/direct arylation reaction.

Author information

1
Davenport Laboratories, Chemistry Department, University of Toronto, Toronto, Ontario, Canada M5S 3H6.

Abstract

A norbornene-mediated palladium-catalyzed tandem alkylation/C-H functionalization sequence is described, in which an alkyl-aryl bond and a heteroaryl-aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides.

PMID:
16173734
DOI:
10.1021/ja054472v
[Indexed for MEDLINE]

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