Format

Send to

Choose Destination
Int J Med Microbiol. 2005 Sep;295(5):335-41.

Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells.

Author information

1
Institute of Experimental Internal Medicine, Medical Faculty, Otto-von-Guericke University, D-39120 Magdeburg, Germany. naumann@medizin.uni-magdeburg.de

Abstract

Helicobacter pylori is a microbial pathogen that colonises the stomach of more than half of the world's human population. H. pylori infection can induce chronic gastritis, peptic ulceration and more rarely, gastric adenocarcinoma. A prominent feature of H. pylori is the presence of a pathogenicity island (PAI) which encodes a type IV secretion system (T4SS). This review focuses on the processes of how H. pylori induces PAI-dependent epithelial cell signalling that might be of importance in gastric inflammation and the pathogenesis of neoplasia.

PMID:
16173500
DOI:
10.1016/j.ijmm.2005.06.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center