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Prostate. 2006 Feb 1;66(2):173-9.

Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project.

Author information

1
Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. slager@mayo.edu

Abstract

BACKGROUND:

Prostate cancer (PC) is a complex disease that displays variable disease outcome, ranging from a relatively indolent disease to forms that result in death from the disease. One measure of disease severity is the Gleason score. Using the Gleason score as a measure of tumor aggressiveness, several independent genome scans have reported evidence of linkage. As of yet, however, no genes have been implicated.

METHODS:

We report an independent genome scan using the Gleason score as a quantitative trait. We genotyped 405 highly polymorphic microsatellite markers in 175 brother pairs from 103 families.

RESULTS:

Our strongest evidence of linkage is to 6q23 at 137 cM (D6S292, P = 0.0009). Other interesting regions (P < 0.005) were on chromosome 1p13-q21 and on chromosome 5p13-q11.

CONCLUSIONS:

Our results provide further evidence that tumor aggressiveness has a genetic component, and that this genetic component may be influenced by several independent genes.

PMID:
16173044
DOI:
10.1002/pros.20332
[Indexed for MEDLINE]

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