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Int J Obes (Lond). 2005 Dec;29(12):1478-83.

Noninvasive assessment of the tension-time index of inspiratory muscles at rest in obese male subjects.

Author information

1
EA 3300 APS and Motor Patterns: Adaptations-Rehabilitation, Sport Science Department, Picardie Jules Verne University, Amiens Cedex, France.

Abstract

OBJECTIVE:

The aim of this study was to investigate the effect of excessive mechanical load caused by obesity on the inspiratory muscle performance in obese men at rest.

METHODS:

We therefore measure at rest spirometric flows and the noninvasive tension time index of inspiratory muscle (TTmus = PI/PImax x TI/TTOT) in eight obese male subjects (body mass index (BMI) > 30) and 10 controls.

RESULTS:

Spirometric flow (FEV1% pred, FVC% pred) and maximal inspiratory pressure (PImax) were significantly lower in obese subjects compared to controls (P < 0.001). The mean TTmus was significantly higher in obese subjects than in controls (0.136 +/- 0.003 vs 0.045 +/- 0.01). The increase in TTmus was primarily due to an increase in the ratio of mean inspiratory pressure to maximal inspiratory pressure (PI/PImax) and the duty cycle (TI/TTOT). We found a significant negative relationship between PImax and BMI (r = -0.74, P < 0.001), a positive correlation between TTmus and BMI (r = 0.80, P < 0.001) and a negative correlation between TTmus and forced expiratory volume in 1 s (r = -0.85, P < 0.001).

CONCLUSION:

Excessive mechanical load caused by obesity imposes a great burden on the inspiratory muscle, which may predispose such subjects to respiratory muscle weakness at rest.

PMID:
16172620
DOI:
10.1038/sj.ijo.0803030
[Indexed for MEDLINE]

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