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Vaccine. 2006 Jan 30;24(5):691-5. Epub 2005 Aug 24.

Oral immunogenicity of a plant-made, subunit, tuberculosis vaccine.

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1
The Biodesign Institute at Arizona State University, School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USA.

Abstract

Transgenic plants are a novel way to produce and deliver oral vaccines. Arabidopsis thaliana material shown previously to express the tuberculosis (TB) antigen ESAT-6 fused to the B subunit of Escherichia coli heat-labile enterotoxin (LTB) was fed to mice and the resulting immune response investigated. The plant-made LTB-ESAT-6 fusion protein induced antigen-specific responses from CD4+ cells and increased IFN-gamma production, indicating a Th1 response. In addition, a Th2 response was induced in the Peyer's patch. This is the first report of an orally delivered, subunit, tuberculosis vaccine priming an antigen-specific, Th1 response.

PMID:
16169639
DOI:
10.1016/j.vaccine.2005.08.009
[Indexed for MEDLINE]
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