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J Infect. 2006 May;52(5):339-45. Epub 2005 Sep 19.

Imported Katayama fever: clinical and biological features at presentation and during treatment.

Author information

1
Department of Clinical Sciences, Institute of Tropical Medicine (IMTA), Nationalestraat 155, 2000 Antwerp, Belgium. ebottieau@itg.be

Abstract

OBJECTIVES:

To investigate the characteristics of imported Katayama fever (acute schistosomiasis) as well as evolution and outcome under treatment.

METHODS:

Between April 2000 and September 2004, we included prospectively all patients with confirmed diagnosis of Katayama fever. Follow-up was maintained at least until 6 months after symptoms resolved. Praziquantel (PZQ) was given as soon as the diagnosis was probable, most of the time with steroids.

RESULTS:

Twenty-three patients were diagnosed with Katayama fever by Schistosoma egg detection and/or by seroconversion. Clinical features were non-specific, with mainly respiratory and/or gastrointestinal symptoms. Diagnosis was confirmed at presentation in 17/23 (74%) patients, of whom 15 by serology. Immediate clinical exacerbation occurred in five of nine patients not given steroids concomitantly with PZQ. After initial resolution, fever recurred in five (22%) patients. When compiling initial and recurrent episodes (n=28), respiratory symptoms tended to occur at an earlier stage after exposure, while abdominal complaints were more frequent later. All patients were completely cured, sometimes after repeated treatments.

CONCLUSIONS:

Clinical presentation of Katayama fever is non-specific and involves respiratory and abdominal symptoms. Recurrence of fever is not unusual despite anti-helminthic treatment. Optimal therapeutic strategy remains to be defined to prevent recurrence.

PMID:
16169593
DOI:
10.1016/j.jinf.2005.07.022
[Indexed for MEDLINE]

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