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Immunity. 2005 Sep;23(3):245-8.

Closer to the source: notch and the nature of thymus-settling cells.

Author information

1
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Abstract

Questions regarding T cell development have recently received much attention, but the earliest intrathymic differentiation steps in adult mice have remained controversial. Three new papers together show that for at least some thymus-settling precursors, the loss of B lineage potential occurs in the thymus, and Notch acts on multipotent progenitors early after thymic entry.

PMID:
16169497
DOI:
10.1016/j.immuni.2005.08.008
[Indexed for MEDLINE]
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