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FEMS Microbiol Lett. 2005 Dec 1;253(1):1-8. Epub 2005 Sep 6.

Norovirus protein structure and function.

Author information

1
Veterinary Molecular Biology, P.O. Box 173610, Montana State University, Bozeman, MT 59717, USA. mhardy@montana.edu

Abstract

Noroviruses are positive strand RNA viruses that have received increased attention in recent years because their role as etiologic agents in acute gastroenteritis outbreaks is now clearly established. Much has been learned about the epidemiology of these viruses and the extent of genetic diversity among circulating strains. In contrast, progress on understanding the basic mechanisms of virus replication has been far slower due to the inability to cultivate virus in the laboratory. Despite this limitation, significant progress has been made in defining some basic functions of the norovirus proteins, and the structures of two have been solved to near atomic resolution. This minireview summarizes these recent advances in understanding the structure and function of the norovirus proteins and provides speculation about what roles they may play in the virus replication cycle.

PMID:
16168575
DOI:
10.1016/j.femsle.2005.08.031
[Indexed for MEDLINE]
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