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Mol Cell. 2005 Sep 16;19(6):724-6.

A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks.

Author information

1
Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Abstract

In a recent study (Moreno-Herrero et al., 2005), atomic force microscopy (AFM) imaging of the human Mre11/Rad50/Nbs1 (MRN) complex engaging substrate DNA revealed large-scale, DNA binding-induced propagation of conformational change to the distal ends of the Rad50 coiled coils and erection of a 1000 A scaffold to productively bridge DNA ends.

PMID:
16168369
DOI:
10.1016/j.molcel.2005.07.006
[Indexed for MEDLINE]
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