Format

Send to

Choose Destination
See comment in PubMed Commons below
Immunobiology. 2005;210(2-4):153-60.

The macrophage scavenger receptor CD163.

Author information

1
Department of Molecular Cell Biology and Immunology, VU Medical Center, P.O. Box 7057, 1007MB Amsterdam, The Netherlands. bo.fabriek@vumc.nl

Abstract

Mature tissue macrophages form a first line of defense to recognize and eliminate potential pathogens; these specialized cells are capable of phagocytosis, degradation of self and foreign materials, establishment of cell-cell interactions, and the production of inflammatory mediators. Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily members. CD163 is a member of the SRCR family class B and is expressed on most subpopulations of mature tissue macrophages. The best characterized function of CD163, which is essentially a homeostatic one, is related to the binding of Hemoglobin:Haptoglobin complexes. Furthermore, it has been suggested that CD163 positive macrophages or the soluble form of CD163 plays a role in the resolution of inflammation, as they are found in high numbers in inflamed tissue.

PMID:
16164022
DOI:
10.1016/j.imbio.2005.05.010
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center