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Chest. 2005 Sep;128(3):1524-30.

Effects of 8-week, interval-based inspiratory muscle training and breathing retraining in patients with generalized myasthenia gravis.

Author information

1
Departament de Pneumology, Area de Rehabilitaci├│n Respiratoria, Hospital de la Santa Creu i de Sant Pau Av, Sant Antoni Maria Claret, 167 08025, Barcelona, Spain. gfreitas@hsp.santpau.es

Erratum in

  • Chest. 2005 Nov;128(5):3779.

Abstract

STUDY OBJECTIVE:

To assess the effect of interval-based inspiratory muscle training (IMT) combined with breathing retraining (BR) in patients with generalized myasthenia gravis (MG) in a partial home program.

DESIGN:

A randomized controlled trial with blinding of outcome assessment.

SETTING:

A secondary-care respiratory clinic.

PATIENTS:

Twenty-seven patients with generalized MG were randomized to a control group or a training group.

INTERVENTIONS:

The training group underwent interval-based IMT associated with BR (diaphragmatic breathing [DB] and pursed-lips breathing [PLB]) three times a week for 8 weeks. The sessions included 10 min each of DB, interval-based IMT, and PLB. Interval-based IMT consisted of training series interspersed with recovery time. The threshold load was increased from 20 to 60% of maximal inspiratory pressure (P(Imax)) over the 8 weeks.

MEASUREMENTS AND RESULTS:

Lung function, respiratory pattern, respiratory muscle strength, respiratory endurance, and thoracic mobility were measured before and after the 8 weeks. The training group improved significantly compared to control group in P(Imax) (p = 0.001), maximal expiratory pressure (P(Emax)) [p = 0.01], respiratory rate (RR)/tidal volume (V(T)) ratio (p = 0.05), and upper chest wall expansion (p = 0.02) and reduction (p = 0.04). Significant differences were seen in the training group compared to baseline P(Imax) (p = 0.001), P(Emax) (p = 0.01), maximal voluntary ventilation (p = 0.02), RR/V(T) ratio (p = 0.003), Vt (p = 0.02), RR (p = 0.01), total time of RR (p = 0.01), and upper chest wall expansion (p = 0.005) and reduction (p = 0.005). No significant improvement was seen in lower chest wall or lung function.

CONCLUSIONS:

The partial home program of interval-based IMT associated with BR is feasible and effective in patients with generalized MG. Improvements in respiratory muscle strength, chest wall mobility, respiratory pattern, and respiratory endurance were observed.

PMID:
16162753
DOI:
10.1378/chest.128.3.1524
[Indexed for MEDLINE]

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