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FEBS Lett. 2005 Oct 31;579(26):5932-9. Epub 2005 Aug 9.

RNAi mechanisms in Caenorhabditis elegans.

Author information

1
Center for Cancer Research, MIT, E17-526, 40 Ames Street, Cambridge, MA 02139, USA. agrishok@mit.edu

Abstract

RNA interference (RNAi) is a form of gene silencing induced by double stranded RNA (dsRNA) that is processed into short interfering RNAs (siRNAs). RNAi can induce both post-transcriptional and transcriptional gene silencing. In Caenorhabditis elegans, there are several distinct pathways where post-transcriptional or/and transcriptional RNAi mechanisms are involved. RNAi in C. elegans is also systemic and heritable. This review will discuss RNAi related pathways, features of RNAi in C. elegans and possibilities of endogenous gene regulation by RNAi.

PMID:
16162338
DOI:
10.1016/j.febslet.2005.08.001
[Indexed for MEDLINE]
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