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Pol Merkur Lekarski. 2005 May;18(107):527-9.

[Coagulation parameters associated with inhaled glucocorticosteroid therapy in stable asthma].

[Article in Polish]

Author information

1
Klinika ChorĂ³b Wewnetrznych, Pneumonologii i Alergologii Akademii Medycznej w Warszawie.

Abstract

The aim of this study was to determine if there are changes in laboratory investigations which allow to recognize coagulation disturbances associated with inhaled glucocorticoid therapy.

MATERIAL AND METHODS:

The study group consist of 26 patients with stable asthma (5 male, 21 female) without risk factors of venous thrombosis, mean age 45 +/- 14 years. 15 patients were treated with 500-1000 mg beclomethasone daily, 11 patients received a daily dose of 1000-2000 microg of beclomethasone. The laboratory investigations included: hemoglobin concentration (Hb), hematocrit (Ht), platelet count (PLT), red blood cell count (E), white blood cell count (L), percentage of eosinophils (Eos%), fibrinogen (Fib), D-dimer concentration, activated partial thromboplastin time (APTT), prothrombin time (PT), prothrombin index (Quick), INR and von Willebrand factor (vWF).

RESULTS:

An elevated concentration of D-dimers was detected in 4 patients (15%) the others investigated coagulation parameters were within normal range. We found a significant correlation between the dose of inhaled glucocorticosteroid and the PT, prothrombin index and INR.

CONCLUSION:

The results revealed no evidence of increased fibrinolytic activity in subjects with stable bronchial asthma treated with inhaled glucocorticosteroids.

PMID:
16161948
[Indexed for MEDLINE]
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