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Mov Disord. 2006 Feb;21(2):258-63.

Co-occurrence of restless legs syndrome and Parkin mutations in two families.

Author information

1
Department of Neurology, University of Lübeck, Lübeck, Germany.

Abstract

Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.

PMID:
16161156
DOI:
10.1002/mds.20690
[Indexed for MEDLINE]

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