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J Bacteriol. 2005 Sep;187(18):6577-9.

The MutS C terminus is essential for mismatch repair activity in vivo.

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  • 1Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.

Abstract

An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutSdelta800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, anti-recombination, and sensitivity to cytotoxic agents in a dam mutant background.

PMID:
16159793
PMCID:
PMC1236653
DOI:
10.1128/JB.187.18.6577-6579.2005
[PubMed - indexed for MEDLINE]
Free PMC Article
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