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Anticancer Res. 2005 May-Jun;25(3B):2135-9.

Cytokine expression in colon carcinoma.

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1
University of Freiburg, Department of Surgery, Freiburg, Germany. baier@chir.ukl.uni-freiburg.de

Abstract

BACKGROUND:

Cytokines reflect the activity of the immune system. We analyzed the local expression of characteristic cytokines indicating the level of activity of unspecific inflammatory cells, Th1-cells and Th2-cells in colon cancer.

MATERIALS AND METHODS:

In 25 tumor/ mucosa pairs, IL-1alpha, IL-2, IL-4, IL-5, IL-15, TNF-alpha and IFN-gamma were measured by real-time PCR.

RESULTS:

There was a significant increase in IL-1alpha, IL-4, IL-5 and TNF-alpha and a significant decrease in IL-2 in tumor tissue compared to normal mucosa.

DISCUSSION:

The cytokine profile in colon cancer indicates a strong unspecific inflammatory reaction in the tumor tissue represented by high levels of IL-1 and TNF-alpha. The comparatively low level of IL-2 suggests suppression of a specific immunological reaction, namely Th1-cells. It can be hypothesized that this is a result and/or cause of local immune escape mechanisms. Furthermore, there is an activation of TH2 cells in the carcinomas.

PMID:
16158955
[Indexed for MEDLINE]
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