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Neurology. 2005 Sep 13;65(5):745-7.

Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.

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1
Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. rosas@helix.mgh.harvard.edu

Abstract

The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.

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