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Arch Neurol. 2005 Sep;62(9):1402-8.

Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia.

Author information

1
Dementia Research Centre, Institute of Neurology, University College London, England.

Abstract

BACKGROUND:

The pathologic substrates of frontotemporal dementia (FTD) are difficult to predict in vivo.

OBJECTIVE:

To determine whether different pathologic substrates of FTD have distinct patterns of regional atrophy on magnetic resonance imaging (MRI).

DESIGN:

Retrospective case study.

SETTING:

The Institute of Neurology, University College London, and the Institute of Psychiatry, King's College London. Patients Twenty-one cases of FTD selected on pathologic grounds (9 with ubiquitin-positive [tau- and alpha-synuclein-negative] inclusions [FTD-U], 7 with Pick disease [PiD], and 5 with familial FTD with tau exon 10+16 mutations [tau exon 10+16]) and 20 healthy controls were studied.

MAIN OUTCOME MEASURES:

Patterns of gray matter atrophy in each group as assessed by voxel-based morphometry (VBM) and a blinded visual assessment of each MRI study.

RESULTS:

All pathologic substrates were associated with atrophy that involved the inferior and medial temporal and inferior frontal lobes. Additionally, specific VBM signatures were identified for each subgroup: FTD-U was associated with asymmetric (left > right) temporal lobe atrophy, PiD was associated with severe dorsolateral bifrontal atrophy, and tau exon 10+16 was associated with asymmetric (right > left) medial temporal lobe atrophy. The VBM findings were supported by blinded visual assessment.

CONCLUSION:

These findings suggest that MRI patterns of regional gray matter atrophy constitute signatures of tissue pathology in FTD.

PMID:
16157747
DOI:
10.1001/archneur.62.9.1402
[Indexed for MEDLINE]

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