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Trends Plant Sci. 2005 Oct;10(10):491-502.

P(1B)-ATPases--an ancient family of transition metal pumps with diverse functions in plants.

Author information

1
School of Biological Sciences, University of Southampton, Southampton, UK SO16 7PX. lew@soton.ac.uk

Abstract

P(1B)-ATPases form a distinct evolutionary sub-family of P-type ATPases, transporting transition metals such as Cu, Zn, Cd, Pb and Co across membranes in a wide range of organisms, including plants. Structurally they are distinct from other P-types, possessing eight transmembrane helices, a CPx/SPC motif in transmembrane domain six, and putative transition metal-binding domains at the N- and/or C-termini. Arabidopsis has eight P(1B)-ATPases (AtHMA1-AtHMA8), which differ in their structure, function and regulation. They perform a variety of important physiological tasks relating to transition metal transport and homeostasis. The crucial roles of plant P(1B)-ATPases in micronutrient nutrition, delivery of essential metals to target proteins, and toxic metal detoxification are discussed.

PMID:
16154798
DOI:
10.1016/j.tplants.2005.08.008
[Indexed for MEDLINE]

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