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Bioorg Med Chem Lett. 2005 Nov 15;15(22):4998-5002.

Pyrazolopyridinones as functionally selective GABAA ligands.

Author information

1
Neuroscience Research Centre, Merck Sharp & Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. Wesley_Blackaby@Merck.com

Abstract

2,5-Dihydro-3H-pyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands, which can exhibit functional selectivity for the alpha3 subtype over the alpha1 subtype. SAR studies to optimize this functional selectivity are described.

PMID:
16153832
DOI:
10.1016/j.bmcl.2005.08.006
[Indexed for MEDLINE]

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