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J Clin Invest. 2005 Oct;115(10):2886-93. Epub 2005 Sep 8.

Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response.

Author information

1
Division of Clinical Immunology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA. andrew.fontenot@uchsc.edu

Abstract

Beryllium exposure can lead to the development of beryllium-specific CD4+ T cells and chronic beryllium disease (CBD), which is characterized by the presence of lung granulomas and a CD4+ T cell alveolitis. Studies have documented the presence of proliferating and cytokine-secreting CD4+ T cells in blood of CBD patients after beryllium stimulation. However, some patients were noted to have cytokine-secreting CD4 T cells in blood in the absence of beryllium-induced proliferation, and overall, the correlation between the 2 types of responses was poor. We hypothesized that the relative proportion of memory T cell subsets determined antigen-specific proliferation. In most CBD patients, the majority of beryllium-specific CD4+ T cells in blood expressed an effector memory T cell maturation phenotype. However, the ability of blood cells to proliferate in the presence of beryllium strongly correlated with the fraction expressing a central memory T cell phenotype. In addition, we found a direct correlation between the percentage of beryllium-specific CD4+ T(EM) cells in blood and T cell lymphocytosis in the lung. Together, these findings indicate that the functional capability of antigen-specific CD4+ T cells is determined by the relative proportion of memory T cell subsets, which may reflect internal organ involvement.

PMID:
16151531
PMCID:
PMC1199530
DOI:
10.1172/JCI24908
[Indexed for MEDLINE]
Free PMC Article

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