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J Pediatr Surg. 2005 Sep;40(9):1390-4.

Lung development is not necessary for diaphragm development in mice.

Author information

1
Division of Pediatric Surgery, Children's Hospital of New York, New York, NY 10032-3784, USA. ma2161@columbia.edu

Abstract

BACKGROUND/PURPOSE:

Congenital diaphragmatic hernia affects approximately 1 in every 2000 live births. The etiology of these diaphragmatic defects is unknown. Using mice with a targeted deletion of fibroblast growth factor 10 (FGF10), which display a complete lack of lung tissue, we have examined the relationship between lung hypoplasia and diaphragmatic development.

METHODS:

The diaphragms of FGF10 null mice were examined at 2 embryonic time-points and compared with their heterozygous and wild-type littermates.

RESULTS:

FGF10 null mice had phenotypically normal diaphragms when compared with wild-type littermates at both time-points studied.

CONCLUSION:

Normal diaphragm development appears to occur independent of lung development in mice.

PMID:
16150338
DOI:
10.1016/j.jpedsurg.2005.05.059
[Indexed for MEDLINE]

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