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Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):606-10.

High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes.

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1
Bi-Valley Medical Clinic, Sacramento, CA, USA. jmccarthy@bivalley.com

Abstract

OBJECTIVE:

This study assesses the effect of higher doses of methadone during pregnancy on maternal and fetal outcomes.

STUDY DESIGN:

We retrospectively reviewed clinical data for 81 mothers who received methadone and their 81 offspring. The cohort was divided into high-dose (>/=100 mg) and low-dose (<100 mg) groups.

RESULTS:

There were no differences in the rate of medication treatment for neonatal abstinence symptoms or days of infant hospitalization between the high-dose (mean, 132 mg) and low-dose (mean, 62 mg) groups. Despite longer histories of opiate abuse, the high-dose group had less illicit drug use at delivery. The whole cohort, which received an average of 101 mg/d, had an 81% rate of negative toxicology screens at delivery.

CONCLUSION:

High doses of methadone were not associated with increased risks of neonatal abstinence symptoms but had a positive effect on maternal drug abuse. Arbitrarily limiting methadone dose as a way of minimizing the risks of neonatal abstinence symptoms may be unwarranted.

PMID:
16150249
DOI:
10.1016/j.ajog.2005.03.072
[Indexed for MEDLINE]
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