Format

Send to

Choose Destination
See comment in PubMed Commons below
EMBO J. 2005 Oct 5;24(19):3353-9. Epub 2005 Sep 8.

Ubiquitylation and cell signaling.

Author information

1
Institute for Biochemistry II, University Hospital of Goethe University, Frankfurt am Main, Germany.

Abstract

Ubiquitylation is an emerging mechanism implicated in a variety of nonproteolytic cellular functions. The attachment of a single ubiquitin (Ub) or poly-Ub (lysine 63) chains to proteins control gene transcription, DNA repair and replication, intracellular trafficking and virus budding. In these processes, protein ubiquitylation exhibits inducibility, reversibility and recognition by specialized domains, features similar to protein phosphorylation, which enable Ub to act as a signaling device. Here, we highlight several recent examples on how Ub regulates signaling and how signaling regulates ubiquitylation during physiological and pathological cellular processes.

PMID:
16148945
PMCID:
PMC1276169
DOI:
10.1038/sj.emboj.7600808
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center