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Clin Diagn Lab Immunol. 2005 Sep;12(9):1135-8.

Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin.

Author information

1
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.

Abstract

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

PMID:
16148186
PMCID:
PMC1235805
DOI:
10.1128/CDLI.12.9.1135-1138.2005
[Indexed for MEDLINE]
Free PMC Article

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