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Front Biosci. 2006 Jan 1;11:852-66.

Mechanisms of X-chromosome inactivation.

Author information

1
Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

Abstract

Mammalian X-chromosome inactivation is an impressive example of epigenetic gene regulation, whereby the majority of genes on the approximately 160 Mb X chromosome are silenced in a strictly cis-limited fashion. In this review we will discuss the important players involved in the silencing process. The process is initiated by transcription and cis-localization of the non-coding XIST RNA, which then recruits many of the epigenetic features generally associated with heterochromatin, including histone modifications, histone variants and DNA methylation.

PMID:
16146776
DOI:
10.2741/1842
[Indexed for MEDLINE]

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