Format

Send to

Choose Destination
Vet Pathol. 2005 Sep;42(5):618-32.

Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.

Author information

1
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA.

Abstract

We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma). Our results document somatic point mutations or deletions encompassing the PTEN C-terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment. This represents the first characterization of a naturally occurring, highly metastatic tumor with biologically significant mutations of PTEN in the C-terminal domain.

PMID:
16145208
DOI:
10.1354/vp.42-5-618
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center