Low concentrations of nitric oxide exert a hormetic effect on Mycobacterium tuberculosis in vitro

William Benjamin Brugmann; Marcia A Firmani

doi:10.1128/JCM.43.9.4844-4846.2005

Low concentrations of nitric oxide exert a hormetic effect on Mycobacterium tuberculosis in vitro

J Clin Microbiol. 2005 Sep;43(9):4844-6. doi: 10.1128/JCM.43.9.4844-4846.2005.

Authors

William Benjamin Brugmann¹, Marcia A Firmani

Affiliation

¹ Louisiana State University Health Sciences Center, School of Allied Health Professions, Department of Clinical Laboratory Sciences, New Orleans, 70112-2223, USA.

Abstract

Susceptibilities of 12 clinical Mycobacterium tuberculosis isolates to acidified sodium nitrite (ASN) were compared. The results demonstrate that 8 of the 12 isolates exhibited enhanced survival levels in 1.5 mM ASN compared to levels in medium alone, suggesting that low concentrations of reactive nitrogen intermediates have a hormetic effect on M. tuberculosis in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Colony Count, Microbial
Culture Media
Dose-Response Relationship, Drug
Humans
Microbial Sensitivity Tests / methods
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / growth & development*
Nitric Oxide / pharmacology*
Reactive Nitrogen Species / pharmacology
Sodium Nitrite / pharmacology
Tuberculosis, Pulmonary / microbiology

Substances

Culture Media
Reactive Nitrogen Species
Nitric Oxide
Sodium Nitrite