Send to

Choose Destination
See comment in PubMed Commons below
South Med J. 2005 Aug;98(8):827-9.

Rhabdomyolysis from Simvastatin triggered by infection and muscle exertion.

Author information

  • 1Department of Neurology, Krankenanstalt Rudolfstiftung, Vienna, Austria.


A 42-year-old woman received a 6-month course of simvastatin (20 mg/d) for hypercholesterolemia. Despite an infection with fever, fatigue, myalgias, and lumbar pain, she continued to perform her regular sports activities. Neurologic examination revealed bilateral ptosis and slight upper limb weakness. Serum creatine kinase was 41,000 U/L. Needle electromyography was nonspecifically abnormal. Discontinuation of simvastatin and reduction of the sports activities was followed by a prompt continual lowering of the elevated muscle enzymes to normal values over a 2-week period. The patient's infection, regular sports activity despite the infection, and a suspected mitochondrial defect were regarded as triggers of rhabdomyolysis.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Southern Medical Association
    Loading ...
    Support Center