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Semin Liver Dis. 2005 Aug;25(3):298-310.

Antinuclear antibodies in primary biliary cirrhosis.

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  • 1Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy. pietro.invernizzi@unimi.it

Abstract

Patients with primary biliary cirrhosis (PBC) generate a variety of autoantibodies, which are primarily directed against mitochondrial antigens (AMA). However, a subgroup of patient sera are also positive for antibodies to nuclear components (ANAs). At indirect immunofluorescence (IIF), PBC sera mostly produce homogeneous, nuclear dot, speckled, centromere, or rim-like patterns. During the last two decades, a number of nuclear structures have been recognized as specific targets of ANA in PBC. These include Sp100 and promyelocytic leukemia proteins, which generate a nuclear dot IIF pattern, and two components of the nuclear pore complex specifically associated with a perinuclear pattern (i.e., gp210 and p62). In recent years, the clinical significance of ANA in PBC has been widely investigated and data indicate that, unlike AMAs, PBC-specific ANAs correlate with disease severity and may therefore be a marker of poor prognosis.

PMID:
16143945
DOI:
10.1055/s-2005-916321
[PubMed - indexed for MEDLINE]
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