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Genetics. 2005 Dec;171(4):1813-22. Epub 2005 Sep 2.

Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila.

Author information

1
Department of Organismic and Evolutionary Biology, The Biological laboratories, 16 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA.

Abstract

Hybrids between species are often characterized by novel gene-expression patterns. A recent study on allele-specific gene expression in hybrids between species of Drosophila revealed cases in which cis- and trans-regulatory elements within species had coevolved in such a way that changes in cis-regulatory elements are compensated by changes in trans-regulatory elements. We hypothesized that such coevolution should often lead to gene misexpression in the hybrid. To test this hypothesis, we estimated allele-specific expression and overall expression levels for 31 genes in D. melanogaster, D. simulans, and their F1 hybrid. We found that 13 genes with cis-trans compensatory evolution are in fact misexpressed in the hybrid. These represent candidate genes whose dysregulation might be the consequence of coevolution of cis- and trans-regulatory elements within species. Using a mathematical model for the regulation of gene expression, we explored the conditions under which cis-trans compensatory evolution can lead to misexpression in interspecific hybrids.

PMID:
16143608
PMCID:
PMC1456106
DOI:
10.1534/genetics.105.047449
[Indexed for MEDLINE]
Free PMC Article

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