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Bioorg Med Chem Lett. 2005 Nov 1;15(21):4854-7.

SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors.

Author information

1
4SC AG, Am Klopferspitz 19a, 82152 Martinsried, Germany. leban@4sc.com

Abstract

Novel DHODH inhibitors were developed based on a previously described series by introduction of heteroatoms into the cyclopentene ring and hydroxyl groups attached to it. Also, the hydrophobic biphenyl side chain was replaced with benzyloxy phenyl groups. Activities on human, rat, and mouse enzymes indicate a species specificity of these inhibitors.

PMID:
16143532
DOI:
10.1016/j.bmcl.2005.07.053
[Indexed for MEDLINE]

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