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J Rheumatol. 2005 Sep;32(9):1843-5.

Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus.

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1
Department of Neurology, Columbia University Neurologic Institute, New York, NY, USA.

Abstract

We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.

PMID:
16142887
[Indexed for MEDLINE]
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