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Trends Parasitol. 2005 Nov;21(11):494-8. Epub 2005 Sep 2.

Drug-resistant malaria.

Author information

1
Faculty of Life Sciences, University of Manchester, Jackson's Mill, PO Box 88, Manchester M60 1QD, UK. john.hyde@manchester.ac.uk

Abstract

In the past 21 years, a modest increase in the range of antimalarial drugs approved for clinical use has been complemented by a more impressive expansion in the analysis and understanding of the molecular mechanisms underlying resistance to these agents. Such resistance is a major factor in the increasing difficulty in controlling malaria, and important developments during this period are recounted here.

PMID:
16140578
PMCID:
PMC2722032
DOI:
10.1016/j.pt.2005.08.020
[Indexed for MEDLINE]
Free PMC Article

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