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Trends Cell Biol. 2005 Oct;15(10):540-7.

Coincidence detection in phosphoinositide signaling.

Author information

1
Department of Biochemistry, School of Medical Sciences, University of Bristol, UK.

Abstract

Phosphoinositide lipids function as both signaling molecules and as compartment-specific localization signals for phosphoinositide-binding proteins. In recent years, both phosphoinositides and phosphoinositide-binding proteins have been reported to display a restricted, rather than a uniform, distribution across intracellular membranes. Here, we examine recent data documenting the restricted distribution of both phosphoinositides and phosphoinositide-binding proteins and examine how phosphoinositide-binding proteins might engage multiple binding partners to achieve these restricted localizations, effectively acting as detectors of coincident localization signals.

PMID:
16139503
PMCID:
PMC1904488
DOI:
10.1016/j.tcb.2005.08.005
[Indexed for MEDLINE]
Free PMC Article

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